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81.
Hai-xiong Sun D.D.S. Kazunori Yoshiura D.D.S. Ph.D. Miho Yamada D.D.S. Naoyuki Yamada D.D.S. Ph.D. Motomasa Sasaki M.D. D.D.S. Ph.D. 《Oral Radiology》1989,5(2):11-15
Unilateral coronoid process atrophy associated with fatty degeneration of the masticatory muscles in a 76-year-old woman is
reported. CT and plain radiogram findings are presented. The patient had no evidence of collagen disease which often causes
osteolysis of the coronoid, process and condyle. Although the true cause of this deformity was unclear, a hypothesis of ischemic
changes in the nutrient vessels was suggested as an etiologic factor. 相似文献
82.
Oxygen and the sugar metabolism in oral streptococci. 总被引:1,自引:0,他引:1
K Abbe J Carlsson S Takahashi-Abbe T Yamada 《Proceedings of the Finnish Dental Society. Suomen Hammasl??k?riseuran toimituksia》1991,87(4):477-487
Streptococci have several ways of adapting themselves to the constantly changing environment of the human oral cavity. This paper discusses the adaptation of sugar metabolism to variations in oxygen levels. In all streptococci the Embden-Meyerhof pathway of glycolysis works under aerobic as well as anaerobic conditions, but pyruvate is converted into different metabolic end products depending on the oxygen levels. Under anaerobic conditions all streptococci form formate, acetate, and ethanol by a pyruvate formate-lyase pathway. If sugar is in excess, they also form lactate using a lactate dehydrogenase. Under aerobic conditions pyruvate formate-lyase is inactivated. This enzyme is then replaced by a pyruvate oxidase in some streptococci and by a pyruvate dehydrogenase in others. The characteristics of these enzymes help streptococci like S. sanguis, S. oralis, S. gordonii, and S. mitis to compete successfully with other bacteria in those sites of the oral cavity that are freely exposed to saliva, while mutans streptococci have to colonize anaerobic sites such as those in-between the teeth and in the occlusal fissures of the teeth. 相似文献
83.
Ohya M Yamada Y Ozawa R Ito K Takahashi M Ueda M 《Clinical oral implants research》2005,16(5):622-629
In the present study, we compared bone regeneration ability in sinus floor elevation between a tissue engineering method using mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP), and a promising new method using particulate cancellous bone and marrow (PCBM) and PRP. Bilateral sinus floor elevation procedures were performed in 18 adult Japanese white rabbits. MSCs/PRP or PCBM/PRP complexes were grafted to each maxillary sinus in the same rabbits. The MSCs were isolated from rabbit iliac crest marrow, and PRP was obtained from peripheral blood. PCBM were collected from the rabbit iliac crest and mixed with PRP. The animals were sacrificed at 2, 4, and 8 weeks after transplantation, and the bone formation ability of each implant was evaluated histologically and histometrically. According to the histological observations, both sites (MSCs/PRP and PCBM/PRP) showed well newly formed bone and neovascularization at 2 and 4 weeks. However, at 8 weeks, the lamellar bone was observed to be occupied by fatty marrow in large areas in both sites. There was no significant difference in bone volume or augmented height between MSCs/PRP and PCBM/PRP groups each week, but there were significant differences in bone volume and augmented height between 2 and 8 weeks in PCBM/PRP or MSCs/PRP groups and in bone volume between 4 and 8 weeks in the PCBM/PRP group (P<0.05). These results suggest that the MSCs/PRP complex may well be used for bone regeneration in sinus floor elevation, compared with the PCBM/PRP complex. 相似文献
84.
Glucose utilization, lactate production and intracellular concentrations of glucose, lactate, glycolytic intermediates and coenzymes were determined at various pH values in Strep. mutans PK 1 and Strep. sanguis NCTC 10904 harvested in the exponential growth phase. Mass-action ratios were compared with equilibrium constants for each reaction of the Embden-Meyerhof pathway and reactions catalysed by the following enzymes were determined to be rate-limiting steps of the pathway at pH 7.0: ATP-glucose phosphotransferase, pyruvate kinase and lactate dehydrogenase in Strep, mutans, ATP-glucose phosphotransferase and pyruvate kinase in Strep, sanguis. Changes induced in intracellular concentrations of glycolytic intermediates by alterations in pH revealed that the decrease in the rate of glycolysis in these organisms at acidic pH values was caused by the inhibition, or damage, of the ATP-glucose phosphotransferase activity. At acidic pH values, Strep, mutans consumed more glucose and produced more lactate than did Strep, sanguis. ATP-glucose phosphotransferase activity in Strep, mutans was inhibited less than that in Strep, sanguis and thus would contribute to the greater tolerance of Strep, mutans to acid. 相似文献
85.
Tanno M Hashimoto S Muramatsu T Matsuki M Yamada S Shimono M 《Journal of periodontal research》2006,41(1):15-22
OBJECTIVES: The aim of this study was to investigate the differential immunolocalization of laminin gamma(2) and integrin beta(4) in primary cultures of the rat gingival epithelium. METHODS: The gingival epithelium was obtained from Sprague-Dawley rats and was cultured in serum-free keratinocyte growth medium (DK-SFM). Western blotting analysis, immunofluorescence, confocal laser scanning microscopy (CLSM), and immuno-gold labeling for laminin gamma(2) and integrin beta(4) were employed. CLSM images for laminin and integrin were analyzed in horizontal (x-y axis) and in vertical (x-z axis) sections. RESULTS: Both laminin gamma(2) and integrin beta(4) were detected by Western blot analysis in the gingival epithelium. Immunolocalization of laminin gamma(2) was distinct in the cytoplasm to form one or two irregular rings in gingival epithelial cells. By contrast, integrin beta(4) was localized diffusely in the cytoplasm. F-actin (indicating actin filaments) was clearly discernible at the periphery of the cytoplasm to form a cellular fringe. In x-z axis images obtained by CLSM, laminin gamma(2) was recognized as large foci in the most inner portion just above the basal plasma membrane. Integrin beta(4) existed in the area where F-actin was labeled surrounding the membrane. Immuno-electron microscopy showed that 10nm colloidal gold particles indicating laminin gamma(2) were mainly localized at the extracellular portion and in the peripheral cytoplasm, whereas integrin beta(4) was distributed in the cytoplasm close to the basal plasma membrane but not in extracellular regions. CONCLUSIONS: In primary cultures of the rat gingival epithelium, both laminin gamma(2) and integrin beta(4) may be produced by the epithelium, and irregular rings of laminin gamma(2) are formed in areas where gingival cells adhere to the extracellular matrix. 相似文献
86.
Fujita T Yamamoto S Ota M Shibukawa Y Yamada S 《The International journal of periodontics & restorative dentistry》2011,31(3):247-253
The aim of this study was to clarify the adjunctive effect of enamel matrix derivative (EMD) on expanded polytetrafluoroethylene membrane guided tissue regeneration (GTR)-based root coverage by creating gingival recessions in beagle dogs. Recessions were treated with GTR + EMD, GTR alone, or neither GTR nor EMD (control). The control group was characterized by long junctional epithelium and little bone formation. The GTR + EMD group showed a statistically significant increase (P < .01) in new bone and cementum formation compared with the GTR group. The results of the present investigation suggest that the adjunctive use of EMD with GTR promotes formation of new bone and cementum without root resorption in recession-type defects in dogs. 相似文献
87.
Effect of porous xenographic bone graft with collagen barrier membrane on periodontal regeneration 总被引:2,自引:0,他引:2
Yamada S Shima N Kitamura H Sugito H 《The International journal of periodontics & restorative dentistry》2002,22(4):389-397
The purpose of this study was to investigate the effect of porous xenographic bone graft (Bio-Oss) with a collagen barrier membrane (Bio-Gide) on formation of new cementum and new bone in experimental intrabony defects of dogs. The intrabony defects were treated by either guided tissue regeneration with the collagen membrane (control group) or the collagen membrane with the porous bone mineral graft (experimental group). After 8 weeks, the animals were sacrificed and the tissues were histologically examined. New cementum with inserting collagen fibers was observed on the exposed surfaces in both groups. The amount of nevv bone was significantly greater in the group using the bone graft with the membrane than in the control group. The use of the collagen barrier membrane in combination with the porous bone graft material may enhance new bone and cementum formation. 相似文献
88.
The role of the succinate pathway in sorbitol fermentation by oral Actinomyces viscosus and Actinomyces naeslundii 总被引:1,自引:0,他引:1
The sorbitol fermentation by Actinomyces viscosus and Actinomyces naeslundii was studied with washed sorbitol-grown cells. The fermentation was followed by titration of acids produced at pH 7.0 under anaerobic conditions. Metabolic end-products and intracellular levels of NAD, NADH and glycolytic intermediates during the fermentation were also analyzed. Cell extracts were examined for certain enzyme activities. Bicarbonate was required for acid production from sorbitol and from a mixture of glucose and sorbitol. Malate and fumarate could also support the acid production of A. viscosus. The main end-products were succinate and lactate but not ethanol. Cell extracts showed no activities of alcohol and aldehyde dehydrogenases, but they had activities of malate dehydrogenase and fumarate reductase. In the absence of bicarbonate, malate or fumarate, the intracellular NADH/NAD ratio increased and the levels of 3- and 2-phospho-glycerate and phosphoenolpyruvate decreased. The results indicate that oral sorbitol-fermenting actinomyces lack the ethanol pathway that can contribute to NADH oxidation. To maintain intracellular redox balance during anaerobic sorbitol fermentation, these bacteria can oxidize surplus NADH through a succinate pathway. 相似文献
89.
Estomaguio GA Yamada K Ochi K Hayashi T Hanada K 《Cranio : the journal of craniomandibular practice》2005,23(4):257-263
This study investigated the association of craniofacial and glenoid fossa shapes and temporomandibular joint (TMJ) pathology in 39 orthodontic patients with signs and symptoms of TMJ disorders, using helical CT scans. Cephalometric measurements showed that 21 subjects with bilateral condylar bone change (BBC) had significantly smaller SNB angles, ramus heights and S-Ar/N-Ba ratios, as well as larger mandibular plane angles and lower anterior facial height than the 18 subjects with no condylar bone change (NBC). The average posterior slope of the left and right articular eminence in their central and lateral sections was significantly steeper in NBC than in BBC. Condylar bone change might, therefore, not only be related to the morphology of the mandible, but also of the glenoid fossa and cranial base. This appears to reflect adaptive changes in the condyle, articular eminence and cranial base in response to changes in loading. 相似文献
90.